UNIVERSITAS AIRLANGGA



Detail Article

Majalah Farmasi Airlangga (Airlangga Journal of Pharmacy)

ISSN 0852-1050

Vol. 7 / No. 2 / Published : 2009-10

Order : 7, and page :36 - 39

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Original Article :

Effect of crosslinker on physical characteristics and  in vitro release of theophylline-chitosan microparticles

Author :

  1. M Agus Syamsur Ridjal*1
  2. Tri Anita S*2
  3. Retno Sari*3
  1. Dosen Fakultas Farmasi
  2. Mahasiswa Fakultas Farmasi
  3. Dosen Fakultas Farmasi

Abstract :

Microparticles of theophylline were prepared using chitosan as polymer and tripolyphosphate (TPP) as cross-linker by orifice-ionic gelation method. The aim of this study was to investigate the effect of cross-linker concentration on physical characteristic, entrapment efficiency and drug release profile. The result showed that the size of microparticles became larger as TPP amount increased. Morphology of microparticles had spherical or almost spherical shape. Entrapment efficiency of microparticles was 48.12 % - 52. 48 %. Whereas released profile of  theophylline from microparticles with 12. 5 % TPP showed the most retarded release

Keyword :

theophylline, chitosan, tripolyphosphate, microparticle, orifice ionic gelation,


References :

1. Bhumkar, D.R and Pokharkar V.B.,(2006) Studies on Effect of pH on Cross-linking of Chitosan with Sodium Tripolyphosphate: A Technical Note. 7(2). p.E1-5. : AAPS Pharm Sci Tech

2. Birnbaum, D. T., and Peppas, L.B.,(2003) Microparticle Drug Delivery System in :Drug Delivery System in Cancer Therapy p. 117-230. : Humana Press Inc.

5. Shu, X.Z. and K.J.Zhu.,(2001) Chitosan/gelatin microspheres prepared by modified emulsification and ionotropic gelation Vol 18 No.2: 237-245. : J. Microencapsulation





Archive Article

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  7. Effect Of Crosslinker On Physical Characteristics And  in Vitro Release Of Theophylline-chitosan Microparticles

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